Supergirl (Volume 7) is one of many series released as part of DC Rebirth, a publishing initiative by DC Comics that saw many series relaunched. Kara lost her powers at the end of her previous comic series. Her attempt to regain them sets a new status quo for the character, one that is more reflective of the Supergirl TV series airing at the time of its publication.
In 2018, the book suffered a brief hiatus as a consequence of DC restructuring the Superman line. Shortly after Steve Orlando's run ending up with #20 it was announced Supergirl's book would return with October 2018's Supergirl #21, helmed by Marc Andreyko and Kevin Maguire.